Faculty Profile

Biochemistry Faculty

Alayne Schroll, PhD

Professor of Chemistry, Leavy Family Chair in Chemistry, Biochemistry Program Director
View Curriculum Vitae

Ph.D. University of Minnesota
B.A. Russell Sage College

Areas of Expertise:

Bio-organic chemistry, more specifically the development of protecting groups for cysteine and selenocysteine for application in the laboratory synthesis of peptides and proteins

Courses I Teach:

  • Biochemistry I and II
  • Chemistry Senior Seminar
  • Organic Chemistry labs

My research helps me to be informed about recent developments, new tools, and instrumental advancements in the field of biochemistry. I’m particularly interested in bio-organic chemistry, more specifically the development of protecting groups for cysteine and selenocysteine for application in the laboratory synthesis of peptides and proteins.

Current Research Area:

For applications in peptide synthesis: developing new protecting groups for the selenol of selenocysteine, and developing milder and orthogonal deprotection chemistry for thiol and selenol protecting groups.

Publications (all peer-reviewed)

Schroll, A.L.; Hondal, R.J. “Further Development of New Deprotection Chemistry for Cysteine and Selenocysteine Side Chain Protecting Groups” Adv Exp Med Biol 2009, ISSN: 0065-2598, 611, 135-136.

Schroll, A.L.; Heintz, N.H. “Chemical footprinting of structural and functional elements of dhfr oriβ during the CHOC 400 cell cycle”, Gene 2004, 332, 139-147.

Schroll, A.L.; Eastep, S.J.; Barany, G., "Synthesis and Characterization of Methoxy(thiocarbonyl)sulfenyl Chloride", J Org Chem 1990, 55, 1475-1479.

Schroll, A.L.; Barany, G., "A New Protecting Group for the Sulfhydryl Function of Cysteine", J Org Chem 1989, 54, 244-247.

Schroll, A.L.; Barany, G., "Novel Symmetrical and Mixed Carbamoyl and Amino Polysulfanes by Reactions of (Alkoxydichloromethyl)polysulfanyl Substrates with NMethylaniline", J Org Chem 1986, 51, 1866-1881.

MacLaury, M.R.; Schroll, A. L., “Metals as Synergistic Fire Retardants inPolyethylene-Silicone Blends”, J Appl Polym Sci 1985, 30, 461-472.

Schroll, A. L.; MacLaury, M.R. “Use of Polymer-Bound Metals as Fire Retardants in Polyethylene-Silicone Blends”, J Appl Polym Sci 1984, 29, 3883-3899.

Barany, G.; Schroll, A.L.; Mott, A.W.; Halsrud, D.A., “A General Strategy for Elaboration of the Dithiocarbonyl Functionality: Application to the Synthesis of Bis(chlorocarbonyl)disulfane and Related Derivatives of Thiocarbonic Acids”, J Org Chem 1983, 48, 4750-4761.

MacLaury, M.R.; Schroll, A.L., "Kinetic and Chemical Analysis of Polymer Pyrolytic Volatiles by Pyrolysis GC and TGA", J Fire and Flammability 1981, 12, 203-207.

Baechler, R.D.; San Filippo, L.J.; Schroll, A.L., "Structural Effects Upon Competitive Decomposition Pathways of Thiosulfoxide Intermediates", Tet Lett 1981, 22, 5247-5250.

Invited Seminar

“Further Development of New Deprotection Chemistry for Cysteine and Selenocysteine Side Chain Protecting Groups” presented as part of Biochemistry Seminar Series, University of Vermont, February 8, 2008.

Research Posters/Presentations Since Joining SMC Faculty

(*SMC student)

Jarvis, P.*; Flemer, S.; Schroll, A.L. “Synthesis, Purification, and Characterization of a New Selenocysteine Derivative” presented as a poster at the 237th American Chemical Society National Meeting, Salt Lake City, March 23, 2009.

Schroll, A.L. “Advances In 1) the Development of New Deprotection Chemistry for Cysteine and Selenocysteine Side Chain Protecting Groups and 2) the Synthesis of a New Selenocysteine Derivative” presented orally at the Northeast Regional Meeting of the American Chemical Society, Burlington VT, June 30, 2008.

Schroll, A.L., Hondal, R.J. “Advances in the Development of New Deprotection Chemistry for Cysteine and Selenocysteine Side Chain Protecting Groups” presented as a poster at the Northeast Regional Meeting of the American Chemical Society, Burlington VT, June 30, 2008.

Jarvis, P.*; Schroll, A.L. “Synthesis, Purification, and Characterization of a New Selenocysteine Derivative” presented as a poster at the Dean’s Reception, SMC, April 12, 2008.

Schroll, A.L., Hondal, R.J. “Further Development of New Deprotection Chemistry for Cysteine and Selenocysteine Side Chain Protecting Groups” presented as a peer-reviewed poster at the 20th American Peptide Society Meeting, Montreal, Canada, June 26-29, 2007.

Schroll, A.L., Hondal, R.J. “Further Development of New Deprotection Chemistry for Cysteine and Selenocysteine Side Chain Protecting Groups”, presented as a poster at the VT EPSCoR Annual Conference, Burlington VT, Mar 28, 2007.

Schroll, A.L., Hondal, R.J. “Synthesis of New Selenocysteine Derivatives for Peptide Synthesis”, presented as a poster at the Vermont Genetics Network Conference, Williston VT, Aug 16, 2006.

Rotondo, J.*, Schroll, A.L. “Synthesis, Characterization, and Use of New Selenocysteine Derivatives”, presented as a poster at the VT EPSCoR Conference, Burlington VT, Aug 15, 2005.

Schroll, A.L., Heintz, N.H. “Chemical footprinting of structural and functional elements of dhfr oriβ during the CHOC 400 cell cycle”, presented as a peer-reviewed poster at the Vermont Cancer Center’s 18th Regional Cancer Research Symposium, Burlington VT,Oct 2-3, 2003.

Schroll, A.L., Heintz, N.H. “Chemical Footprinting of Three DNA Regions within the Dihydrofolate Reductase Gene of CHOC 400 Cells”, presented as a poster at VT EPSCoR’s Partnerships in Science and Technology Symposium, UVM, Dec 5, 1995.

Schroll, A.L. “Chemical Footprinting of Three DNA Regions within the Dihydrofolate Reductase Gene of CHOC 400 Cells”, presented orally at SMC, Math/Science Seminar Series, Oct 19, 1995.

Crockett, C.*; Schroll, A.L. “The Development of New Protecting Groups for the Sulfhydryl Function of Cysteine”, presented orally by the student at the VT Academy of Arts and Sciences Symposium on Undergraduate Research, Caselton College VT, Apr 1993.

Kopach, M.G.*, Schroll, A.L. “Development of a New Protecting Group for the Sulfhydryl Function of Cysteine”, presented orally by the student at the VT Academy of Arts and Sciences Symposium on Undergraduate Research, Trinity College, Apr 1989.

I co-authored the article (currently in press), "Further Development of New Deprotection Chemistry for Cysteine and Selenocysteine Side Chain Protecting Groups" in Proceedings of the 20th American Peptide Symposium (2008). I presented a poster on this work at several conferences, including at the Northeast Regional IDeA Conference, hosted by the Vermont Genetics Network.

In 2007, I was awarded a faculty development grant for my work on "Synthesis, Purification, and Characterization of a New Selenocysteine Derivative for Use in Peptide/Protein Synthesis."  

Professional Society Memberships:

American Chemical Society

American Peptide Society

 

My Saint Michael's:

If you do not want to get lost in the crowd, Saint Michael's College may be the place for you.

I enjoy working with students very closely. In several cases, I met students when they were looking at Saint Michael's, then advised and taught them while they were here, and now I maintain contact with them as alumni. It is an incredible experience and honor to witness (sometimes play an important role in) the transformations that students undergo during their time here. By and large, our students are honest, caring, good people.

Students have the opportunity to do lab-based research with chemistry faculty during summers and the academic year. Also, students get a variety of experience working for the department, doing general lab maintenance, lab preparative work, instrument maintenance, and sometimes assisting professors during the lab periods.

Alayne Schroll, professor of chemistry and Leavy Chair in chemistry, for a second time served as the Chemistry Olympiad Coordinator for the Green Mountain Section of the American Chemical Society (ACS). For her efforts in organizing the event for the state, Alayne was acknowledged as an ACS 2017 Local Section Outreach Volunteer. The competition was held at Saint Michael's College on Saturday April 22.  The four Vermont students were among over 1,200 students nationwide who took the national qualifying exam.  Twenty students will be identified and will undergo intensive training and screening June 6-21, 2017 at the U.S. Air Force Academy in Colorado.  From that group, the top four will be chosen to represent the U.S. in the 49th International Chemistry Olympiad in Tbilisi, Georgia, July 6-15, 2017. Also, Alayne and former Saint Michael’s student Alexandru Sasuclark (’16, biochemistry) were co-authors on a paper published in April. The full citation is as follows: Payne, N.C.; Geissler, A; Button, A; Sasuclark, A.R.; Schroll, A.L.; Ruggles, E.L.; Gladyshev, V.N.; Hondal, R.J. “Comparison of the redox chemistry of sulfur- and selenium-containing analogs of uracil” Free Rad Bio and Med  2017, 104, 249-261.  The paper reports the results of a research collaboration between Alayne and Professor Robert Hondal of the University of Vermont Biochemistry and Chemistry Departments.
(posted June 2017)

Alayne Schroll, professor of chemistry and Leavy Family Chair in Chemistry, joined with Alexandru Sasuclark (biochemistry major, 2016) to present a research poster titled  “Synthesis, Purification, and Characterization of N-(9-fluorenylmethoxycarbonyl)-Se-tert-butylthio-L-selenocysteine” at the American Chemical Society National Meeting in San Diego CA on March 14, 2016.
(posted June 2016)

Learn What Matters